Bfl-1 is an antiapoptotic Bcl-2 family member and a mouse A1 homologue. The mouse A1 has been reported to have three isoforms, but little is known about human Bfl-1. By reverse–transcriptase ...
Mechanistically, cell death results from the combined inhibition of the prosurvival activity of factors like Bcl-2 and Bcl-xL by BH3-only proteins, together with the activation of Bax or Bak. 4, 5, 6 ...
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