Over the past decade, small molecule kinase inhibitors have emerged as promising therapeutics, particularly in oncology. Through data that has emerged during this period, it has become increasingly ...

The quantification of proteins is an integral part of biopharmaceutical R&D. From the crude quantitation of hybridoma expression profiles of monoclonal antibodies, to quantitative determination of ...

To choose the best lead candidates during drug and antibody screening, scientists characterize a molecule’s binding properties, such as kinetics and affinity. Robust assay design reduces experimental ...

Analytical testing for biologics is evolving rapidly as new protocols become available and companies seek to expedite current methodologies. This article offers expert insight into bioassays and ...

Establishing that a molecule engages with its intended target protein in cells is an essential step in drug discovery and chemical probe development. The term “target engagement” refers to a chemical ...

Covalent (irreversible) Bruton’s tyrosine kinase (BTK) inhibitors have transformed the treatment of multiple B-cell cancers, especially chronic lymphocytic leukemia (CLL). However, resistance can ...

Antibody drugs such as monoclonal antibodies (mAb), bispecific antibodies, antibody-drug conjugates (ADCs), and nanobodies garnered increased interest in research and development circles. Sino ...

Autoclaved peanuts show reduced allergenicity and improved tolerability in peanut allergy. Discover how this could transform ...