Structural and mechanistic insight into Holliday-junction dissolution by Topoisomerase IIIα and RMI1
Repair of DNA double-strand breaks via homologous recombination can produce double Holliday junctions (dHJs) that require enzymatic separation. Topoisomerase IIIα (TopIIIα) together with RMI1 ...
A type of filamentous protein assembly known as agglomerates appear to offer advantages in intracellular engineering and synthetic biology and little to no deleterious effects on cellular fitness, ...
Testing the dissolution rates of a pharmaceutical formulation (also known as in vitro availability) aids drug quality control and is a compulsory requirement of the British, European and US ...
The Central Drugs Standard Control Organisation (CDSCO) has declared 1,190 as standard quality (SQ) based on testing done on 1,204 samples in the month of February 2021. However, it concluded that ...
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Understanding Particle Drift and its Influence on Oral Drug Absorption Using Flux Tools
In this interview, Karl Box from Pion outlines the benefits of particle drift analysis using flux tools and how this can be used to enhance oral drug absorption in pharmaceutical research. Pion's ...
The Central Drugs Standard Control Organisation (CDSCO) in its monthly surveillance report pan-India has declared 731 drugs as standard quality (SQ) based on analysis and testing done on 746 samples ...
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