Guanine nucleotide exchange factors (GEFs) are pivotal regulators of small GTPases that orchestrate membrane traffic, a process fundamental to organelle function and intracellular communication. By ...
RAB7A plays a central role in the final stages of autophagy, facilitating autophagosome-lysosome fusion, lysosome positioning, and cargo degradation. Its activation by guanine nucleotide exchange ...
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