Curran had been looking at an inhibitor of the Hedgehog (Hh) pathway for its potential therapeutic effects on a childhood brain cancer, medulloblastoma (MB). Approximately a third of patients with MB, ...

Studies of signal transduction have yielded a wealth of information about the molecules required to transmit signals from the cell surface to the nucleus. Yet it still remains unknown how a signaling ...

SAN DIEGO--(BUSINESS WIRE)--Endeavor BioMedicines, a clinical-stage biotechnology company developing medicines with the potential to deliver transformational clinical benefits to patients with ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...