Researchers have identified a molecule sent by fat cells to the fly brain that senses when they have had enough food and inhibits feeding. Researchers have identified a molecule sent by fat cells to ...

Although the presence of a BH4 domain distinguishes the antiapoptotic protein Bcl-2 from its proapoptotic relatives, little is known about its function. BH4 deletion converts Bcl-2 into a proapoptotic ...

Apoptosis is an essential physiological process that leads to the selective elimination of cells in metazoans, and it is involved in a variety of biological events. The mitochondria often play a ...

'Reverse engineering' the BH4 pathway reveals sepiapterin reductase as a new target for analgesic treatments. This take on Michelangelo's famous Sistine Chapel image symbolizes the link between human ...

Now, however, a surprising discovery about BH4 will likely rekindle interest in the once-promising pathway and could have profound implications for treating autoimmunity and cancer. In today's Nature, ...