HIGH-GRADE serous ovarian cancer (HGSOC) exhibits two distinct metabolic subtypes, with high oxidative phosphorylation (OXPHOS) tumours showing greater chemosensitivity and low OXPHOS tumours ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cellular metabolism must adapt to changing ...
Figure 1 BET inhibition is synthetic lethal to OXPHOS blockage in liver cancer. Left: GDH1-dependent glutamine metabolic remodeling upon BET inhibition. Right: “Synthetic lethality” targeting OXPHOS ...
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Introduction: Mitochondria are central energy generators for the heart, producing adenosine triphosphate (ATP) through the oxidative phosphorylation (OXPHOS) system. However, mitochondria also guide ...
MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) is an OXPHOS disease mostly caused by the m.3243A>G mutation in the mitochondrial tRNA Leu(UUR) gene. Recently, we ...
Redox regulation of breast cancer underlies malignant progression. Loss of the antioxidant glutathione peroxidase 2 in breast cancer cells increases reactive oxygen species, thereby activating hypoxia ...
In this article, Nelson et al. carried out systematic biochemical characterization of mitochondrial functions between leukemic cells and normal leukocytes. The authors show that intrinsic limitations ...
Specific mechanisms linking inflammation and metabolic reprogramming—two hallmarks of many pathobiological processes—remain incompletely defined. Metabolomic profiling, glucose labeling and tracing, ...
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