Background Intestinal fibrosis, a hallmark complication of Crohn’s disease (CD), frequently progresses to stricture formation and surgical intervention. Fibroblast metabolic reprogramming is important ...
On Wednesday, FibroBiologics, Inc. (NASDAQ: FBLG) submitted a new patent application with the U.S. Patent and Trademark Office (USPTO). The patent application covers a proprietary fibroblast-derived ...
A study funded in part by the National Institutes of Health (NIH) has revealed important insights into the genetics of deposits in the eye, known as reticular pseudodrusen (RPD), that are linked to ...
Senescent fibroblasts are aging cells in connective tissue that no longer divide and protect against tumor development. Yet, these same cells can promote cancer growth in a laboratory setting. Until ...
OPG inhibits cytotoxic function of T effector cells. (A–B) Data are from single-cell RNA sequencing (scRNA-seq) of 12 human esophageal carcinoma tumor samples, derived from biopsies or resections, as ...
This study presents an important finding by identifying OPG as a novel stromal checkpoint influencing T-cell anti-tumor responses, thereby shedding new light on the complex interplay between the tumor ...
Members of the Nobel Committee for Chemistry hold a model of a metal-organic framework during the 2025 prize announcement in Stockholm on October 8. Jonathan Nackstrand / AFP via Getty Images Three ...
Cancer cells can brainwash their neighbors. Like the CIA deploying secret agents to turn an enemy, tumors use a similar strategy to manipulate nearby cells. The tumors’ agents are mitochondria, the ...
Healing from any injury involves a delicate balance between scarring and inflammation — two processes that can wreak havoc as well as make repairs. When the injury is to the brain, the balance is that ...
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